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Pain accounts for 47.7% share of global Central Nervous System clinical trial activity in 2020

Pain accounted for a 47.7% share of the global clinical trials within the Central Nervous System therapy area in 2020, registering an increase of 2.0% when compared with the last ten-year average of 45.7% share, according to GlobalData.

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Non-industry sponsored trials outnumber industry sponsored trials for Pain

Industry sponsored trials held a 20.8% share of all the clinical trials for Pain indication in 2020, registering a decrease of 0.9% when compared with the ten-year average of 21.7%. Non-industry sponsored trials accounted for a 79.2% share in 2020, registering an increase of 0.9% over the ten-year average of 78.3%.

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Top regions of industry sponsored Pain trials

Asia-Pacific was the top region for industry sponsored Pain trials, accounting for a 53.2% share in 2020, when compared with the five-year average of 38.2% and ten-year average of 34.1%.

North America was at the second position with a 29.8% share in 2020, over the five-year average of 38.8% and ten-year average of 40.8%, followed by Europe with a 21.8% share in 2020, as against five-year and ten-year averages of 28.3% and 30.8% respectively.

Middle East and Africa stood fourth with a 1.5% share in 2020, compared with the five-year average of 4.2% and ten-year average of 3.7%, followed by South and Central America with a 1.2% share in 2020, over five-year and ten-year averages of 2.7% and 2.6% respectively.

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The US was the top country for industry sponsored Pain trials, accounting for a 28.6% share in 2020, as against the five-year average of 36.3% and ten-year average of 38.2%.

China held a 24.9% share in 2020, over the five-year average of 13.4% and ten-year average of 7.9%, followed by Russia with an 11.1% share in 2020, compared with the five-year and ten-year averages of 7.2% and 6.7% respectively.

India held a 9.5% share in 2020, as against the five-year average of 6.3% and ten-year average of 7.7%.

Spain held a 5.8% share in 2020, over the five-year and ten-year averages of 6.0% and 5.5% respectively.

Top regions of non-industry sponsored Pain trials

Asia-Pacific was the top region for non-industry sponsored Pain trials, accounting for a 42.1% share in 2020 when compared with the five-year average of 39.3% and ten-year average of 33.6%.

Middle East and Africa was at the second position with a 23.7% share in 2020, over the five-year and ten-year averages of 24.8% and 24.0% respectively, followed by Europe with a 16.9% share in 2020, as against the five-year average of 17.3% and ten-year average of 20.8%.

North America stood at the fourth position with a 16.3% share in 2020, compared with the five-year average of 16.5% and ten-year average of 19.5%, followed by South and Central America with a 1.5% share in 2020, over the five-year and ten-year averages of 2.4% and 2.5% respectively.

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China was the top country for non-industry sponsored Pain trials, accounting for an 18.8% share in 2020, as against the five-year average of 11.8% and ten-year average of 8.3%.

The US held a 14.3% share in 2020, over the five-year average of 13.7% and ten-year average of 16.2%, followed by India with a 13.2% share, compared with the five-year and ten-year averages of 13.8% and 10.3% respectively.

Egypt held a 10.9% share in 2020, as against the five-year average of 7.7% and ten-year average of 4.7%.

Iran held a 10.2% share in 2020, over the five-year average of 14.9% and ten-year average of 16.6%.

Phase I trials lead industry sponsored clinical trials for Pain in 2020

Phase I trials held a 41.3% share of industry sponsored clinical trials for Pain in 2020, over the five-year average of 35.2% and ten-year average of 34.4%.

Phase II trials held a 23.5% share in 2020, as against the five-year average of 29.2% and ten-year average of 26.9%. Phase III trials held a 19.8% share in 2020, compared with the five-year and ten-year averages of 24.0% and 24.9% respectively.

Phase IV trials held a 15.3% share in 2020, over the five-year average of 11.7% and ten-year average of 13.8%.

Phase II trials lead non-industry sponsored clinical trials for Pain in 2020

Phase II trials held a 43.3% share of non-industry sponsored clinical trials for Pain in 2020, over the five-year average of 53.7% and ten-year average of 51.7%.

Phase IV trials held a 25.5% share in 2020, as against the five-year average of 24.8% and ten-year average of 27.8%. Phase III trials held a 17.9% share, compared with the five-year and ten-year averages of 16.1% and 15.6% respectively.

Phase I trials held a 13.3% share in 2020, over the five-year average of 5.4% and ten-year average of 4.9%.

Methodology:
The clinical trials data used for the analyses were extracted from the Clinical Trials Database of GlobalData’s Pharma Intelligence Center. Clinical Trials are sourced from numerous government, non-government and company clinical trial registries worldwide alongside clinical research publications, scientific conferences, company websites, SEC filings and more. The information is gathered by a combination of automation and secondary research to ensure accuracy and validity. A small number of Phase 0, Phase I/II, Phase II/III, and Phase III/IV trials were combined with Phase I, Phase II, Phase III, and Phase IV trials, respectively.

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